MONOPHOSPHATE DERIVATIVES OF LUTEOLIN AND APIGENIN AS EFFICIENT PRECURSORS WITH IMPROVED ORAL BIOAVAILABILITY IN RATS

Monophosphate Derivatives of Luteolin and Apigenin as Efficient Precursors with Improved Oral Bioavailability in Rats

Luteolin (Lut) and apigenin (Apn), flavones present in various edible plants, exhibit diverse antioxidant and pharmacological activities but have limited in vivo efficacy due to low water solubility and poor bioavailability.Here, we generated luteolin and apigenin monophosphate derivatives Cooktop Knob Seal (LutPs and ApnPs) individually via microb

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Treatment-resistant schizophrenia: How far have we traveled?

Treatment-resistant Deals schizophrenia is a lack of adequate response to antipsychotic medications resulting in incomplete functional and social recovery from the illness.Different definitions have been proposed for clinical practice and research work.Antipsychotics that are used in the management of schizophrenia mainly act on multiple dopaminerg

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